A 45-year-old patient with a family history of CRC (father diagnosed with ascending colon cancer at 64 years of age, dying at 68 years of age). It was found in a family screening colonoscopy of an ascending colon lesion of 18 mm with morphology LST-G / IIa + IIc. The lesion was resected with a hybrid technique due to the poor maneuverability of the colonoscope and severe submucosal fibrosis.