We describe the case of a 79-year-old woman with 15 mm choledocholithiasis who could not be removed by conventional methods (sphincterotomy and balloon, mechanical lithotripsy and sphincteroplasty) due to the interlocking of the middle choledochal stones. Holmium laser lithotripsy is performed with Spyglass DS cholangioscopy with success. The fragments in their entirety are extracted with Fogarty balloon